Nootropics
46 compounds
Bromantane
Bromantane is a synthetic compound in the adamantane family that was originally developed in Russia and is often described in research discussions as an adaptogen with mild stimulant like effects. Unlike classic stimulants that can feel overly “wired,” it is typically framed as supporting physical and mental output with a calmer edge, including anxiety reducing properties in some contexts. Interest also extends to its potential to support stress tolerance, recovery, and cellular energy production. Research shows that Bromantane may modulate dopamine synthesis and stress-adaptation pathways without causing the jitteriness associated with standard stimulants.
Flmodafinil (CRL-40,940)
CRL-40,940 also known as Flmodafinil is a bis-fluoro analog of modafinil studied for its wakefulness-promoting and cognitive-enhancing properties. Research indicates it may demonstrate higher bioavailability, longer duration, and cleaner stimulant signaling compared to modafinil and adrafinil.
Phenibut
Phenibut is a synthetic GABA derivative that originated in Russia and is discussed as a nootropic with anxiolytic and sleep support properties. Because it is structured to cross the blood brain barrier more effectively than typical GABA supplements, it is often used in research discussions around relaxation, stress modulation, and improved sleep quality.
9-ME-BC
9-ME-BC (9-methyl-β-carboline) is a synthetic small molecule in the beta-carboline family that is discussed for its dopaminergic and neurotrophic signaling effects, with additional interest tied to monoamine oxidase (MAO) inhibition and neuroinflammation-related pathways.
Noopept
Noopept is a synthetic nootropic compound derived from the racetam family and discussed for its cognitive enhancing and neuroprotective properties. It is often described as highly potent compared to classic racetams, meaning it is commonly used at much lower doses. Research interest focuses on how it modulates neuronal signaling and supports brain health markers tied to memory, focus, and resilience.
Cerebrolysin
Cerebrolysin is a porcine-derived peptide complex composed of low–molecular-weight neuropeptides and amino acids. In research settings, it is studied for its potential neuroprotective, neurotrophic, and cognitive-supportive properties. Its diverse peptide mixture is believed to mimic the activity of endogenous neurotrophic factors.
Tesofensine
Tesofensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) originally developed in neurodegenerative disease research, later identified for strong appetite suppression and weight loss signals in anti-obesity research contexts.
Methylene Blue
Methylene Blue (MB) is a laboratory dye and redox active compound widely used in mitochondrial, neuroprotection, and cellular energy research. Its ability to act as an alternative electron carrier in the mitochondrial electron transport chain makes it a useful research tool for studying mitochondrial efficiency, oxidative stress, and cellular energy signaling in experimental models.
1,3 DMAA
DMAA (1,3 dimethylamylamine) is a synthetic stimulant originally developed as a nasal decongestant in the 1940s. It later became popular in pre workout and fat loss formulas due to its strong stimulant effects.
Dihexa
Dihexa (also known as PNB 0408) is an angiotensin IV derived oligopeptide that binds hepatocyte growth factor (HGF) and potentiates downstream HGF c Met signaling. In research contexts, it is discussed primarily for synaptogenesis and cognitive function endpoints in animal models of impairment, with an emphasis on its apparent brain penetration and oral activity.
Phenylpiracetam Hydrazide
Phenylpiracetam Hydrazide is a modified analog of phenylpiracetam designed to explore similar cognitive and neuromodulatory pathways while offering a distinct pharmacological profile. Preclinical studies suggest it may influence cholinergic signaling, NMDA/AMPA glutamate modulation, and pathways associated with learning, memory, and physical performance.
RGPU-95 (p-CL-Phenylpiracetam)
RGPU-95, also labeled as p-CL-Phenylpiracetam, is an investigational racetam class research compound that appears to be a substituted phenylpiracetam analog. In laboratory settings, it is primarily discussed in the context of cognition, alertness, and performance oriented neuropharmacology models where racetam derivatives are used to probe excitatory neurotransmission, cholinergic tone, and stress resilient cognitive output. RGPU-95 is not approved for human or veterinary use and is supplied strictly for laboratory research purposes.
CE-123
CE-123 is an experimental dopaminergic modulator derived from the modafinil family, investigated for its potential wakefulness-promoting, cognitive-enhancing, and pro-motivational properties. Preclinical data suggest it may selectively influence dopamine transporter (DAT) activity with reduced peripheral stimulation compared to classical stimulants.
J-147
J-147 (a curcumin-derived phenyl hydrazide) is an experimental neurotrophic compound widely explored in preclinical research for its potential cognitive and neuroprotective effects. Studies suggest it may modulate mitochondrial ATP synthase, enhance neurotrophic signaling, and reduce age-related cellular stress.
Aniracetam
Aniracetam (1-p-anisoyl-2-pyrrolidinone) is a member of the racetam class investigated for its potential cognitive, neurotrophic, and anxiolytic properties in preclinical research. Studies suggest Aniracetam may modulate AMPA receptors and influence cholinergic and glutamatergic pathways.
N-189
NSI-189 (NSI-189 phosphate) is an aminopyridine–nicotinamide derivative investigated for its potential neurogenic and antidepressant effects in preclinical and early clinical models. Research suggests it may promote hippocampal neurogenesis and support structural plasticity.
PRL-8-53
PRL-8-53 (Methyl 3-[2-(benzyl(methyl)amino)ethyl]benzoate) is a synthetic nootropic compound investigated for its potential to enhance memory formation, learning speed, and cognitive performance. Preclinical and early human research suggest PRL-8-53 may influence cholinergic signaling, dopamine modulation, and neurochemical processes related to memory encoding.
Oxiracetam
Oxiracetam is a synthetic compound in the racetam family, frequently explored for its potential cognitive-enhancing, neuroprotective, and learning-related effects in research models. Studies suggest it may modulate cholinergic neurotransmission, influence AMPA receptor signaling, and support memory-related pathways.
BPAP
BPAP (Benzofuranylpropylaminopentane) is a long-acting monoamine potentiator explored for its potential to enhance dopaminergic, serotonergic, and noradrenergic activity in preclinical models. It differs from classical stimulants by amplifying neurotransmitter release in response to normal physiological signaling rather than forcing large, acute spikes.
ODY (FCS)
ODY (FCS) is a multi-compound nootropic formulation combining three research ingredients: choline chloride, acetyl L-carnitine, and L-carnosine. Each component has been historically evaluated for its influence on cholinergic signaling, mitochondrial energetics, antioxidant defense, and cognitive-performance pathways. Because ODY (FCS) delivers all three in one sterile solution, it is frequently explored in models involving brain-energy metabolism, fatigue resistance, and neurotransmitter support.
Hydrafinil (Fluorenol)
Hydrafinil (also known as Fluorenol or 9-Fluorenol) is a eugeroic-class research compound historically investigated for its wakefulness-promoting, cognition-supporting, and low-stimulant behavioral profile. Early exploratory literature suggests Hydrafinil may modulate pathways associated with alertness, fatigue resistance, and executive-function performance without the dopaminergic overstimulation characteristic of traditional stimulants.
L-Tetrahydropalmatine (L-THP)
L-Tetrahydropalmatine (L-THP) is a plant-derived isoquinoline alkaloid historically isolated from Corydalis species. It has been extensively studied in preclinical and historical literature for its effects on dopaminergic signaling, stress response, analgesia, and anxiolytic pathways. Unlike stimulant-class nootropics, L-THP is generally characterized by its calming, dopaminergic-modulating profile rather than direct dopaminergic stimulation.
Alpha-GPC
Alpha GPC (L-alpha-glycerylphosphorylcholine) is a choline-containing compound studied for its role in acetylcholine synthesis, neuronal membrane support, and cognitive-performance pathways. It is a bioavailable choline donor that readily crosses the blood-brain barrier, making it a frequent subject of research involving memory, learning, neuromuscular signaling, and brain-energy metabolism.
Agomelatine
Agomelatine is a melatonergic research compound studied primarily for its effects on circadian-rhythm regulation, sleep architecture, and mood-related neurochemical pathways. It is distinct from traditional serotonergic antidepressant models in that it acts as an agonist at melatonin receptors while antagonizing specific serotonin receptors, making it a compound of interest in chronobiology, sleep research, and mood-stability models.
PPAP (Phenylpropylaminopentane)
PPAP (Phenylpropylaminopentane) is a synthetic monoaminergic research compound structurally related to phenethylamine derivatives and historically studied for its unique activity-dependent neuromodulatory properties. Unlike classical stimulants that directly force neurotransmitter release, PPAP is investigated for its ability to amplify catecholamine signaling only when neurons are already active, making it a compound of interest in motivation, focus, and performance-efficiency models rather than raw stimulation.
TAK-653
TAK-653 is a novel glutamatergic research compound developed as a positive allosteric modulator (PAM) of AMPA receptors. It is primarily studied for its ability to enhance synaptic plasticity, cognitive processing, and neurotrophic signaling without directly agonizing glutamate receptors. Because of its selective, activity-dependent mechanism, TAK-653 has attracted interest in research related to cognition, depression, and synaptic resilience.
Coluracetam
Coluracetam is a synthetic racetam-class research compound studied primarily for its effects on cholinergic neurotransmission and sensory processing. Unlike classical racetams that broadly modulate acetylcholine usage, Coluracetam is notable for its ability to enhance high-affinity choline uptake (HACU), a rate-limiting step in acetylcholine synthesis. This distinct mechanism has made it a compound of interest in cognition, sensory perception, and mood-related research models.
Piracetam
Piracetam is a synthetic nootropic from the racetam family that was first developed in the 1960s and is often discussed as one of the original “smart drug” style compounds. In research and nootropic communities, it is primarily used for cognition support, especially memory, learning, and overall mental performance. While its exact mechanism is not fully established, it is commonly described as a compound that supports neurotransmission efficiency and brain energy utilization.
ISRIB
ISRIB (Integrated Stress Response Inhibitor) is a small-molecule research compound studied for its ability to modulate the integrated stress response (ISR) at the level of protein translation. Rather than preventing cellular stress signaling, ISRIB is investigated for its capacity to restore normal protein synthesis downstream of stress activation. This has positioned it as a compound of interest in cognition, memory consolidation, neuroplasticity, and recovery-from-stress research models.
CDP-Choline (Citicoline)
CDP-Choline, also known as Citicoline or cytidine diphosphate choline, is an endogenous intermediate in phosphatidylcholine synthesis and a widely studied choline donor in neuroscience research. Unlike simple choline salts, CDP-Choline supplies both choline and cytidine. Cytidine is converted in vivo to uridine, supporting neuronal-membrane synthesis, acetylcholine production, and dopaminergic-signaling pathways.
ALT-711 (Alagebrium Chloride)
ALT-711, also known as Alagebrium Chloride, is a synthetic research compound developed to target advanced glycation end products (AGEs). It is primarily studied for its ability to break pre-existing AGE cross-links in proteins, which distinguishes it from compounds that merely slow glycation formation. This mechanism has made ALT-711 a compound of interest in aging, vascular elasticity, metabolic stress, and tissue-stiffness research models.
Fasoracetam
Fasoracetam is a racetam-class research compound distinguished by its effects on metabotropic glutamate receptors (mGluRs) and cholinergic signaling rather than direct glutamate or dopamine stimulation. Originally developed for neuropsychiatric research, Fasoracetam has become a compound of interest in cognition, executive function, attention regulation, and neurodevelopmental-signaling models. Unlike classic racetams, Fasoracetam is often discussed for its regulatory and normalizing effects on neurotransmission rather than for purely amplifying cognitive output.
Nefiracetam
Nefiracetam is a nootropic compound in the racetam family that was originally developed for cognitive decline and neurological disorders. Like other racetams, it is used for cognitive support, but it is also known for potential mood support and anxiety reduction. It is fat soluble, which may help it cross the blood brain barrier more easily than water soluble racetams.
IPAM (Indolepropionamide)
IPAM (Indolepropionamide) is an indole-based research compound structurally related to indole-3-propionic acid (IPA), a naturally occurring microbial metabolite derived from tryptophan metabolism. It has been studied for its antioxidant capacity, mitochondrial-protective properties, and neuroprotective signaling effects, making it a compound of interest in cognitive-resilience, aging, and oxidative-stress research models. Unlike classic nootropics that act through neurotransmitter modulation, IPAM is primarily investigated for its cellular-protection and redox-balancing roles.
1,4 DMAA
1,4 DMAA (1,4-dimethylamylamine) is a synthetic aliphatic amine studied in laboratory settings for its sympathomimetic and stimulant-like properties. It is structurally related to other dimethylamylamine analogs and has been investigated for its effects on arousal, alertness, and catecholaminergic signaling. In research contexts, 1,4 DMAA is examined as a central-nervous-system stimulant model compound rather than as a cognitive nootropic in the traditional sense.
Adrafinil
Adrafinil is a synthetic eugeroic-class research compound originally developed to promote wakefulness and reduce fatigue. It is a prodrug of modafinil, meaning it is metabolized into modafinil after administration in biological systems. Because of this indirect conversion, Adrafinil is primarily studied in wakefulness, alertness, and fatigue-resistance research models rather than in classic stimulant paradigms.
Chlodantane
Chlodantane is a synthetic adamantane-derived research compound structurally related to other adamantane analogs studied for their effects on wakefulness, fatigue resistance, and cognitive endurance. Compounds in this class have historically been explored for their ability to influence arousal systems and central-nervous-system activation without classic amphetamine-like stimulation. Chlodantane is primarily examined in alertness and performance-sustainment models rather than in memory-formation or neuroplasticity-focused research.
Nooglutyl
Nooglutyl, also known as Nooglutil, is a synthetic nootropic research compound studied in Russia for potential applications in amnesia and cognitive-impairment models. Chemically, it is N-(5-hydroxynicotinoyl)-L-glutamic acid and is sometimes discussed as having structural similarities to picamilon-type scaffolds, including nicotinoyl-linked amino-acid derivatives.
Emodin
Emodin is a naturally occurring anthraquinone compound found in several plants, commonly including rhubarb species and related botanicals. In research, it is explored for its potential effects on inflammatory signaling, oxidative stress, metabolic regulation, and cellular stress-response pathways. Emodin is not typically categorized as a classic nootropic. It is more often studied as a bioactive compound that may indirectly influence brain and body performance by affecting systemic inflammation, mitochondrial stress, and cellular-signaling networks.
Sunifiram
Sunifiram is a synthetic nootropic research compound sometimes grouped with ampakine-like cognitive enhancers because of its apparent effects on glutamatergic signaling and synaptic plasticity. It is structurally distinct from racetams but is often discussed within the same cognitive-performance category because of its reported potency at low-milligram ranges in exploratory models. Sunifiram is primarily studied for potential applications in learning, memory consolidation, and synaptic efficiency rather than stimulant-style wakefulness.
HBT1 (YDL233C)
HBT1 (also referenced as YDL233C) is a research compound studied as an AMPA receptor potentiator. It is commonly discussed in the context of glutamatergic signaling, synaptic plasticity, and downstream neurotrophic signaling, including BDNF related pathways.
Unifiram
Unifiram is a synthetic research nootropic commonly grouped with ampakine-like cognitive compounds because of its association with glutamatergic signaling and synaptic-plasticity pathways. It is often discussed alongside Sunifiram because both appear active at low-milligram ranges in exploratory models and are primarily studied for their potential effects on learning, memory formation, and cognitive throughput rather than classic stimulant-style wakefulness. Unifiram is typically characterized as a high-potency, dose-sensitive compound, so research discussions generally emphasize careful titration and conservative experimental design.
Modafiendz
Modafiendz is a research compound marketed and discussed as a wakefulness and productivity oriented agent. It is typically grouped with “eugeroic style” compounds in terms of intended research use cases, meaning it is explored for sustained alertness, reduced fatigue, and improved task endurance rather than classic amphetamine like stimulation. Because “Modafiendz” is a branded or lab designated name rather than a standardized INN drug name, researchers usually treat it as a distinct research material and focus on observed functional outcomes and conservative design rather than assuming it behaves identically to any single reference compound.
CMS-121
CMS-121 is a small-molecule research compound primarily explored in preclinical models for its potential neuroprotective and pro-longevity signaling effects. In research contexts, it is most often discussed in relation to cellular-stress resilience, oxidative-stress modulation, and the preservation of neuronal function under metabolic or inflammatory strain. CMS-121 is commonly positioned as a candidate in cognitive-aging and neurodegeneration-oriented research designs in which mitochondrial performance, lipid peroxidation, and inflammatory signaling are key variables.
GB-115
GB-115 is an anxiolytic (anti anxiety) dipeptide originally developed in Russia and marketed there as Ranquilon. It’s a CCK (cholecystokinin) related compound that’s been researched for anxiety reduction without the classic “benzo haze” profile people worry about.
Seltorexant
Seltorexant, also known by the developmental designations JNJ-42847922 and MIN-202, is a selective orexin-2 receptor antagonist (2-SORA) under active clinical investigation for major depressive disorder, insomnia, and Alzheimer's disease. Its molecular structure features a fluorine atom and triazole ring that create a precise three-dimensional shape enabling highly selective binding to the OX2 receptor with over 100-fold greater affinity for OX2R over OX1R. This selectivity is clinically significant: the orexin-2 receptor specifically governs arousal suppression and sleep-wake transitions, and blockade of OX2R normalizes the excessive arousal that characterizes conditions like major depressive disorder and insomnia without the broad receptor activity of dual orexin receptor antagonists. Clinical trials have demonstrated both antidepressant and sleep-promoting effects with a favorable safety and tolerability profile. Available in capsule, powder, and liquid formats with purity verified at greater than or equal to 98% via HPLC.