CDP-Choline (Citicoline)
Shop CDP-Choline (Citicoline) on KimeraChems · code GUIDE (10% off)Definition
CDP-Choline, also known as Citicoline or cytidine diphosphate choline, is an endogenous intermediate in phosphatidylcholine synthesis and a widely studied choline donor in neuroscience research. Unlike simple choline salts, CDP-Choline supplies both choline and cytidine. Cytidine is converted in vivo to uridine, supporting neuronal-membrane synthesis, acetylcholine production, and dopaminergic-signaling pathways.
Available Formats
- Dry-fill capsules
- 500 mg per capsule
- 60-count capsules
- 30 g total
Mechanism of Action
Research indicates CDP-Choline supports cognitive and neuronal health through multiple complementary mechanisms: These combined effects make CDP-Choline distinct from other choline donors that act primarily through acetylcholine-related pathways.
- Provides choline for acetylcholine synthesis
- Supplies cytidine for phospholipid synthesis and membrane repair
- Increases phosphatidylcholine availability in neuronal membranes
- Enhances dopaminergic signaling in frontal cortical regions
- Supports mitochondrial-membrane integrity and energy metabolism
- Promotes neuroplasticity and synaptic maintenance
Areas of Investigation
CDP-Choline is commonly studied in
- Memory and learning research
- Attention and executive-function models
- Acetylcholine-related neurotransmission
- Dopaminergic and motivational pathways
- Neuroprotection and recovery models
- Age-related cognitive decline
- Cerebral blood-flow and metabolic studies
Safety Profile
Reported or historically noted findings include: CDP-Choline is generally well tolerated, with side effects most often associated with excessive cholinergic stimulation rather than direct toxicity.
- Mild headache, typically cholinergic in nature
- Gastrointestinal discomfort
- Restlessness or irritability at higher doses
- Insomnia when administered late in the day
Interaction Notes
CDP-Choline is frequently studied alongside compounds that may benefit from enhanced cholinergic and membrane-support pathways
For educational purposes only. Not for human consumption.