SR-9009 (Stenabolic)
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SR-9009 (commonly referred to as Stenabolic) is an investigational research compound frequently studied in metabolic and circadian biology. Unlike selective androgen receptor modulators (SARMs), SR-9009 does not act through the androgen receptor. Instead, it is primarily investigated as a synthetic ligand for the REV-ERBα and REV-ERBβ nuclear receptors, which regulate circadian rhythms and downstream metabolic gene expression. SR-9009 is not approved for human or veterinary use and is supplied strictly for laboratory and analytical research purposes.
Mechanism of Action
SR-9009 is studied as a REV-ERB (REV-ERBα and REV-ERBβ) agonist-like ligand in laboratory research. REV-ERB receptors function as transcriptional repressors that coordinate circadian timing and multiple metabolic processes. Common areas of mechanistic investigation include: Because experimental outcomes are highly dependent on dosing schedule, administration timing, and study design, circadian alignment is considered a critical variable when interpreting results.
- Circadian gene regulation: Studied for its ability to modulate clock-gene expression through REV-ERB-mediated signaling
- Mitochondrial metabolism: Investigated for effects on transcriptional programs governing mitochondrial function and oxidative metabolism in skeletal muscle and liver models
- Lipid metabolism: Explored in studies evaluating fatty-acid oxidation and lipid-handling pathways under controlled metabolic conditions
- Inflammatory signaling: Studied in selected immune and tissue models for circadian-linked effects on inflammatory signaling pathways
- Energy expenditure: Investigated for indirect effects on energy expenditure and activity-related endpoints in animal research
Areas of Investigation
SR-9009 is commonly studied in
- Circadian biology and clock-gene regulation
- Skeletal-muscle oxidative capacity and endurance-related research
- Lipid metabolism and hepatic-fat-handling studies
- Mitochondrial biogenesis and metabolic-flexibility research
- Circadian regulation of inflammatory and immune signaling
- Body-composition research with standardized dietary intake and activity variables
Safety Profile
Reported observations are model- and exposure-dependent and may include
- Sleep- or circadian-disruption findings when administration timing conflicts with the experimental light-dark cycle
- Changes in appetite or activity patterns in certain animal models
- Fatigue-, lethargy-, or altered-recovery-related findings depending on dosing schedule
- Off-target signaling concerns resulting from broad transcriptional effects associated with nuclear receptor modulation
- Skin-irritation findings in certain topical-application studies
Interaction Notes
SR-9009 is often investigated alongside interventions that overlap with circadian and metabolic signaling.
For educational purposes only. Not for human consumption.